Impact Factor 2017 = 1.086 has been issued by ISI Web of Knowledge (JCR 2017).
ISSN 1998-9539
Two most common synthetic approaches (i.e. the esterification and 1,3-dipolar cycloaddition reactions) to a functionalization of the reactive three-dimensional molecular platforms, allowing to obtain the fluorescently labeled iron(II) clathrochelates and, therefore, to study their localization and accumulation in cancer cells, were compared. Because an esterification approach gave them in very low, if any, yields, such functionalization of a known propargylamine iron(II) clathrochelate complex with terminal CºC bond as a reactive macrobicyclic precursor by the copper-promoted 1,3-dipolar cycloaddition “click”-reaction was also tested. This one-pot synthetic procedure allowed to obtain the cumarin-terminated iron(II) cage complex in the high yield; it was characterized using elemental analysis, ESI-TOF mass, and 1H and 13C{1H} NMR spectra.