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ISSN 1998-9539

Photoinactivation of S. Aureus by Сationic meso-Arylporphyrin and Its Zn(II) Complex

Inga O. Savelyeva,a Yulia S. Bortnevskaya,a Alexey Yu. Usanev,a Natal’ya A. Bragina, Andrey F. Mironov,a Anastasia A. Ignatova,b Alexey V. Feofanov,b,c and Kseniya A. Zhdanovaa@

aMIREA – Russian Technological University, 119571 Moscow, Russian Federation

bShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russian Federation

cBiological Faculty, Lomonosov Moscow State University, 119992 Moscow, Russian Federation

@Corresponding author E-mail: zhdanova_k@mirea.ru

 

DOI: 10.6060/mhc210130z

Macroheterocycles 2021 14(2) 140-146

 

In this work, cationic meso-arylsubstituted porphyrin and its Zn(II) complex were synthesized. The compounds were characterized by multinuclear NMR spectroscopy, electronic spectroscopy and ESI-mass spectrometry. The photodynamic activity of the porphyrins was studied in relation to S. aureus bacteria and their biofilms. Application of polymeric micelles of Pluronic F-127 as nanosized delivery vehicles supports high antimicrobial photodynamic activity of the synthesized porphyrins. The influence of the central metal atom on the dark and light-induced toxicity of the synthesized compounds was revealed.

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