Photoinactivation of S. Aureus by Сationic meso-Arylporphyrin and Its Zn(II) Complex

Inga O. Savelyeva,^a Yulia S. Bortnevskaya,^a Alexey Yu. Usanev,^a Natal’ya A. Bragina, Andrey F. Mironov,^a Anastasia A. Ignatova,^b Alexey V. Feofanov,^b,c and Kseniya A. Zhdanova^a@

^aMIREA – Russian Technological University, 119571 Moscow, Russian Federation

^bShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russian Federation

^cBiological Faculty, Lomonosov Moscow State University, 119992 Moscow, Russian Federation

^@Corresponding author E-mail: zhdanova_k@mirea.ru

DOI: 10.6060/mhc210130z

Macroheterocycles 2021 14(2) 140-146

In this work, cationic meso-arylsubstituted porphyrin and its Zn(II) complex were synthesized. The compounds were characterized by multinuclear NMR spectroscopy, electronic spectroscopy and ESI-mass spectrometry. The photodynamic activity of the porphyrins was studied in relation to S. aureus bacteria and their biofilms. Application of polymeric micelles of Pluronic F-127 as nanosized delivery vehicles supports high antimicrobial photodynamic activity of the synthesized porphyrins. The influence of the central metal atom on the dark and light-induced toxicity of the synthesized compounds was revealed.

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Photoinactivation of S. Aureus by Сationic meso-Arylporphyrin and Its Zn(II) Complex

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