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ISSN 1998-9539

Low Symmetric meso-Borneol and meso-Carbazole Substituted H3Corroles: Synthesis, Characterization and Their Anticancer Behaviors

Rongping Tang,a Zhouqun Ji,b Lin Xie,a Hongyan Lu,b Wei Tang,b@1 and Xu Lianga,c@2

aLanzhou Petrochemical College of Vocational Technology, Lanzhou 730050, P. R. China

bDepartment of Pediatrics, Affiliated Hospital of Jiangsu University, Zhenjiang 210000, P. R. China

cSchool of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. China

@1Corresponding author E-mail: zjtangwei@163.com

@2Corresponding author E-mail: liangxu@ujs.edu.cn

 

DOI: 10.6060/mhc200920l

 

Two A2B type free base corroles with meso-borneol substituents at the B position have been synthesized and characterized. A detailed analysis of the optical and redox properties was carried out, and a comparison was made with theoretical calculations to identify the key trends in the structure-property relationships. The meso-borneol substituent couples strongly with the porphyrin core leading to significant CD signals in the B band region. Enhanced anti-cancer properties are observed in vitro relative to the introduction of (-)-borneol units.