Low Symmetric meso-Borneol and meso-Carbazole Substituted H3Corroles: Synthesis, Characterization and Their Anticancer Behaviors

Rongping Tang,^a Zhouqun Ji,^b Lin Xie,^a Hongyan Lu,^b Wei Tang,^b@1 and Xu Liang^a,c@2

^aLanzhou Petrochemical College of Vocational Technology, Lanzhou 730050, P. R. China

^bDepartment of Pediatrics, Affiliated Hospital of Jiangsu University, Zhenjiang 210000, P. R. China

^cSchool of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. China

^@1Corresponding author E-mail: zjtangwei@163.com

^@2Corresponding author E-mail: liangxu@ujs.edu.cn

DOI: 10.6060/mhc200920l

Macroheterocycles 2021 14(1) 87-93

Two A₂B type free base corroles with meso-borneol substituents at the B position have been synthesized and characterized. A detailed analysis of the optical and redox properties was carried out, and a comparison was made with theoretical calculations to identify the key trends in the structure-property relationships. The meso-borneol substituent couples strongly with the porphyrin core leading to significant CD signals in the B band region. Enhanced anti-cancer properties are observed in vitro relative to the introduction of (–)-borneol units.

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Low Symmetric meso-Borneol and meso-Carbazole Substituted H3Corroles: Synthesis, Characterization and Their Anticancer Behaviors

References: