Журнал "Макрогетероциклы"

Truong H. Hieu,^a,e Alexandra I. Komarova,^b Alexander N. Levov,^b Anatoly T. Soldatenkov,^b† Elena I. Polyakova,^b Nguyen V. Tuyen,^a,d Dang T. T. Anh,^a,d Alena N. Kulakova,^b Victor N. Khrustalev,^b and Le T. Anh^c@

^aInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam

^bDepartment of Inorganic Chemistry, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation

^cFaculty of Chemistry, VNU University of Science, Vietnam National University, Hanoi, Vietnam

^dGraduate University of Science and Technology, VAST, Hanoi, Vietnam

^eSaigon Pharmaceutical Science-Technology Centre, University of Medicine and Pharmacy at Ho Chi Minh City, 70000 Ho Chi Minh City, Vietnam

^@Corresponding author E-mail: huschemical.lab@gmail.com

DOI: 10.6060/mhc190554a

Macroheterocycles 2019 12(4) 409-414

The transformations of dibenzo[(γ-piperidono]aza-14-crown-4 ethers were implemented with Li-organic compounds and sodium borohydride under reduction condition. The structures of new compounds were confirmed by ¹H NMR, IR, MS analysis. X-Ray single-crystal structure study has exactly determined the structure of the representative compound 2g. According to the PASS program, these obtained new azacrown ethers containing γ-piperidol fragment are interested to develop new biologically active agents such as a CYP2H substrate (60–95 %), membrane permeability inhibitor (60–74 %) and spasmolytic agent (60–92 %).