Synthesis of Nanosized Monocationic β-Cyclodextrin Conjugates Containing Residues of Pharmacologically Important Acids

Dmitry A. Shipilov,^a@ Galina I. Kurochkina,^a Aleksander A. Sergievich,^b and Mikhail K. Grachev^a

^aMoscow State University of Education, 129164 Moscow, Russia

^bFar Eastern Federal University, 690091 Vladivostok, Russia

^@Corresponding author E-mail: shda90@mail.ru

DOI: 10.6060/mhc170510s

Macroheterocycles2017 10(2) 238-242

New nanosized cationic β-cyclodextrins conjugates containing residues of pharmacologically important monocarbonic aromatic acids at the primary hydroxyl groups were synthesized with the use of benzoic, p-aminobenzoic, nicotinic and i-nicotinic acids. The position of substituents in carbohydrate fragments of CDs was unambiguously determined by ¹H and ¹³C NMR spectroscopy. During the investigation, some features of the regiodirected synthesis of such nanosized cationic β-cyclodextrins conjugates were revealed.

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Synthesis of Nanosized Monocationic β-Cyclodextrin Conjugates Containing Residues of Pharmacologically Important Acids

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