Impact Factor 2021 = 1.200 has been issued by ISI Web of Knowledge (JCR 2021).

SCImago Journal & Country Rank

ISSN 1998-9539

The Antioxidant Properties of Asymmetrically Substituted Tetra(meso-aryl)porphyrins with One Phenolic Substituent: The Contribution of Phenol and Porphyrin Fragments to Antioxidant Activity

T. K. Rocheva,a O. G. Shevchenko,b L. I. Mazaletskaya,с N. I. Sheludchenko,с and D. V. Belykha@
aInstitute of Chemistry, Komi Scientific Center, Ural Division, Russian Academy of Sciences, 167000 Syktyvkar, Russia
bInstitute of Biology, Komi Scientific Center, Ural Division, Russian Academy of Sciences, 167982 Syktyvkar, Russia
cEmanuel Institute of Biochemical Physics,Russian Academy of Sciences, 119334 Moscow, Russia
@Corresponding author E-mail:,
DOI: 10.6060/mhc170302b
Macroheterocycles 2018 11(1) 95-102

In this paper we synthesized a series of tetra(meso-aryl)porphyrins with phenolic hydroxyl group in one aromatic substituent and their analogs with methoxy group and estimated antioxidant activity of the compounds obtained by the ability to inhibit peroxidation (LPO) of brain lipids of laboratory mice (in vitro). The porphyrins having phenolic hydroxyl group at para-position in the meso-substituents exhibit the highest antioxidant activity in this model system. When studying  the model reaction of ethylbenzene oxidation, the most high antiradical activity was revealed for the porphyrins with para-phenolic hydroxyl group, what is in agreement with their antioxidant activity. The introduction of additional electron donating groups into the phenolic moiety increases the reactivity of the hybrid molecule relativelyfree radicals.


mhc170302b.pdf630.34 KB