Novel Podands Containing N-Arylthiosemicarbazide Moiety

Le Tuan Anh,^a@ Dao Thi Nhung,^a Le Anh Tuyet,^a Tran Thi Thanh Van,^a Truong Hong Hieu,^b,c Nguyen Van Tuyen,^c,d Nguyen Thi Thanh Phuong,^a Anatoly T. Soldatenkov,^e Vasily E. Kotsuba,^e and Dang Thi Tuyet Anh^c,d

^aUniversity of Science, Vietnam National University, Hanoi, Vietnam

^bDepartment of Biotechnology, Vietnam-Russia Tropical Centre, Hanoi, Vietnam

^cInstitute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam

^dGraduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam

^ePeoples’ Friendship University of Russia, 117198 Moscow, Russia

^@Corresponding author E-mail: anhlt.vnu@gmail.com

DOI: 10.6060/mhc170289l

Macroheterocycles 2017 10(2) 243-246

Six novel biological active podands based on N-arylthiosemicarbazide were synthesized from 1,5-bis(2-formylphenoxy)-3-oxapentane or 1,8-bis-(2-formylphenoxy)-3,6-dioxaoctane. All podands have tested cytotoxicity on human cancer cell lines RL, MCF7, RD, and HepG2 and antimicrobial activity.

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