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ISSN 1998-9539

Synthesis of Hydroxy Derivatives of Chlorin e6

Olga I. Gushchina,@ Milana Yu. Grishina, Ekaterina A. Larkina, Victoriya S. Lebedeva, and Andrey F. Mironov

Moscow Technological University (Institute of Fine Chemical Technologies), 119571 Moscow, Russia

@Corresponding author E-mail:


DOI: 10.6060/mhc161072g

Macroheterocycles 2017 10(1) 81-83


There is a simple scheme of synthesis of new chlorin photosensitizers (PS) based on chlorin е6 hydroxy derivatives. For the disclosure of exocycle of the initial compounds – pheophorbide a and its methyl ester we used aliphatic aminoalcohols with 2-6 carbon atoms in the alkyl chain. The reaction was carried out under mild conditions in chloroform/dichloromethane with heating up to 40 °С. The structure of all compounds obtained was confirmed by means of electronic, IR, 1Н NMR spectroscopy and mass-spectrometry. The yields of compounds 2a-e and3b-e were 60–75 %. It is necessary to note that chlorin е6 hydroxy derivatives 2a-e could be soluble in water using alkaline compounds as excipients (namely KOH, NaOH). This fact is important and valuable because many effective porphyrin and chlorin PS are insoluble in water systems and obtaining of chlorin е6 is time-consuming and hard work. Thus, in this paper we propose a reliable scheme of synthesis of new chlorin’s photosensitizers which are promising agents for PDT. 


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