Журнал "Макрогетероциклы"

Lyudmila N. Lysenkova,^a@1 Ivan A. Godovikov,^b Alexander M. Korolev,^a Valery N. Danilenko,^c Olga B. Bekker,^c Dilara A. Mavletova,^c Aleksey A. Vatlin,^c Andrey E. Shchekotikhin,^a,d@2 and Maria N. Preobrazhenskaya^а

^aG.F. Gause Institute of New Antibiotics, 119021 Moscow, Russian Federation

^bA.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991 Moscow, Russian Federation

^cN.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991 Moscow, Russian Federation

^dD.I. Mendeleev University of Chemical Technology of Russia,  125047 Moscow, Russian Federation

^@1Corresponding author E-mail: lyudmil-lys@yandex.ru

^@2Corresponding author E-mail: shchekotikhin@mail.ru

DOI: 10.6060/mhc151084s

Macroheterocycles 2015 8(4) 424-428

A novel way of chemical modification of the antibiotic oligomycin A at the 2-oxypropyl side chain was developed. Previously obtained 33-O-mesyl oligomycin A was used at the reaction with the potassium thiocyanate to produce (33S)-33-deoxy-33-thiocyanatooligomycin in 66 % yield. (33S)-33-Deoxy-33-thiocyanatooligomycin A has demonstrated a lower potency active against S. fradiae and S. albus than oligomycin A.