Interaction of Cob(III)alamins with Hypothiocyanite. Evidence for the Formation of Hypothiocyanitocobalamin

Ilia A. Dereven’kov,^@ and Vladimir S. Osokin

Ivanovo State University of Chemistry and Technology, 153000 Ivanovo, Russia

^@Corresponding author E-mail: derevenkov@gmail.com

DOI: 10.6060/mhc201128d

Macroheterocycles 2021 14(2) 153-156

Here, we report the results of investigation of the reactions between cobalamins (Cbls) and hypothiocyanite (OSCN^–), a product of thiocyanate oxidation by hydrogen peroxide in the presence of lactoperoxidase. In the case of aquacobalamin, the product, the UV-vis spectrum of which differs from the UV-vis spectra of Cbl(III)-complexes with SCN^–, SO₃^2-, OCN^– and CN^– anions, is formed and attributed to hypothiocyanitocobalamin. This complex reacts with selenomethionine at substantially lower rate than the free OSCN^–. Cyano- and methyl-Cbls are relatively stable in the presence of OSCN^–. Glutathionylcobalamin is transformed to hypothiocyanitocobalamin in the presence of OSCN^– excess via the oxidation of glutathionyl-ligand and subsequent binding of OSCN^– by Cbl(III).

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Interaction of Cob(III)alamins with Hypothiocyanite. Evidence for the Formation of Hypothiocyanitocobalamin

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