Click Synthesis of Triazole-Linked Polyazamacrocycles through Selective Isopimaric Acid Transformations

Marya A. Gromova,^a Yurii V. Kharitonov,^b Tatyana V. Rybalova,^b and Elvira E. Shults^b^@

^aNovosibirsk State Pedagogical University (NSPU), 630126 Novosibirsk, Russia

^bNovosibirsk Institute of Organic Chemistry SB RAS (NIOCH SB RAS), 630090 Novosibirsk, Russia

^@Corresponding author E-mail: schultz@nioch.nsc.ru

DOI: 10.6060/mhc200817s

Macroheterocycles 2021 14(1) 105-111

The first macrocyclic pimarane type diterpenoids containing fragments of 1,2,3-triazole and tricyclic diterpenoid isopimaric acid moieties were synthesized. The key step was the CuAAC reaction of various diazides with the dialkyne derivative obtained from 16-(carboxyphenyl)isopimaric acid. The molecular structure of the macrocyclic compound with 1,5-diazopentane unit was determined by single crystal X-ray diffraction analysis.

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Click Synthesis of Triazole-Linked Polyazamacrocycles through Selective Isopimaric Acid Transformations

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