Synthesis, NMR Spectroscopic Study of α-, β- and γ-Cyclodextrin Inclusion Complexes of 2-Deoxyecdysone and Their Anti-inflammatory Activity

Aizhan M. Kozhanova,^a,b Borash I. Tuleuov,^a@ Perizat K. Kudabayeva,^a Bakhtiyar S. Temirgaziyev,^a Tulegen M. Seilkhanov,^c Roza B. Seidakhmetova,^a Lyazat K. Salkeyeva,^d and Sergazy M. Adekenov^a

^aInternational Research and Production Holding «Phytochemistry», 100009 Karaganda, Republic of Kazakhstan

^bKaraganda Medical University, 100012 Karaganda, Republic of Kazakhstan

^cSh. Ualikhanov Kokshetau State University, 020000 Kokshetau, Republic of Kazakhstan

^dE.A. Buketov Karaganda State University, 100026 Karaganda, Republic of Kazakhstan

^@Corresponding author E-mail: info@phyto.kz

DOI: 10.6060/mhc200602t
Macroheterocycles 2020 13 (3) 292-297

2-Deoxyecdysone-3β,14α,22R,25-tetrahydroxy-5β(Н)-cholest-7-ene-6-one has been isolated from Silene wolgensis (Hornem.) Bess. ex. Spreng. of Caryophyllaceae Juss. family for the first time. The complex formation of phytoecdysteroid with α-, β- and γ-cyclodextrins has been studied by NMR spectroscopy. Based on the change in the chemical shifts of protons of substrate and receptors, it has been established that 2-deoxyecdysone interacts with α-, β- and γ-cyclodextrins with formation of supramolecular inclusion complexes of 1:1 stoichiometric ratio with the entry of ring A of the steroid nucleus of the substrate molecule into the internal cavity of the receptor. Anti-inflammatory activity of the complexes has been studied.

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Synthesis, NMR Spectroscopic Study of α-, β- and γ-Cyclodextrin Inclusion Complexes of 2-Deoxyecdysone and Their Anti-inflammatory Activity

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