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ISSN 1998-9539

Synthesis, NMR Spectroscopic Study of α-, β- and γ-Cyclodextrin Inclusion Complexes of 2-Deoxyecdysone and Their Anti-inflammatory Activity

Aizhan M. Kozhanova,a,d Borash I. Tuleuov,a@ Perizat K. Kudabayeva,a Bakhtiyar S. Temirgaziyev,a Tulegen M. Seilkhanov,b Roza B. Seidakhmetova,a Lyazat K. Salkeyeva,c and Sergazy M. Adekenova

aInternational Research and Production Holding «Phytochemistry», 100009 Karaganda, Republic of Kazakhstan

bSh. Ualikhanov Kokshetau State University, 020000 Kokshetau, Republic of Kazakhstan

cE.A. Buketov Karaganda State University, 100026 Karaganda, Republic of Kazakhstan

dKaraganda Medical University, 100012 Karaganda, Republic of Kazakhstan

@Corresponding author E-mail: info@phyto.kz

 

2-Deoxyecdysone-3β,14α,22R,25-tetrahydroxy-5β(Н)-cholest-7-ene-6-one has been isolated from Silene wolgensis (Hornem.) Bess. ex. Spreng. of Caryophyllaceae Juss. Family For the first time. The complex formation of phytoecdysteroid with α-, β- and γ-cyclodextrins has been studied by NMR spectroscopy. Based on the change in the chemical shifts of substrate protons and receptors, it has been established that 2-deoxyecdysone interacts with α-, β- and γ-cyclodextrins with the formation of supramolecular inclusion complexes of 1:1 stoichiometric ratio with the entry of ring A of the steroid nucleus of the substrate molecule into the internal cavity of the receptor. Anti-inflammatory activity of the complexes has been studied.