Bis-pyrazolylpyridine Complexes of Some Transition Metal Ions: Structure-Activity Relationships and Biological Activity

Ana Rilak Simović,^a Jovana Bogojeski,^b Biljana Petrović,^b and Snežana Jovanović-Stević^a@

This review is dedicated to Professor Rudi van Eldik on the occasion of his 75th birthday

^aUniversity of Kragujevac, Institute for Information Technologies Kragujevac, Department of Natural Science, Jovana Cvijića bb, 34000 Kragujevac, Serbia

^bUniversity of Kragujevac, Faculty of Science, Radoja Domanovića 12, 34000 Kragujevac, Serbia

^@Corresponding author E-mail: snezanaj@kg.ac.rs

DOI: 10.6060/mhc200499s
Macroheterocycles 2020 13(3) 201-209

In this review we summarize our work on development of metallocomplexes with pincer type ligands such as bis-pyrazolylpyridine and its camphor derivatives. The review focuses on the correlation between the kinetics reactivity, DNA/protein interactions and cytotoxicity of these metallocomplexes. In order to establish the structure-activity relationship for the metal-based drugs, we have designed, synthesized and thoroughly studied the complexes with several transition metal ions: Pt(II), Pd(II), Au(III) and Rh(III). The first part of the present review is focused on the kinetic study of the ligand substitution reactions of complexes with small biomolecules (5’-GMP and some amino acids). The second part of the review is about DNA/BSA interactions of these complexes and last part is about cytotoxicity of Pt(II), Pd(II), Au(III) and Rh(III) complexes on different cell lines. Systematic summary of these results will contribute to the future development of transition metal ion complexes as potential antitumor agents and will have importance to understand the potential toxicity of metal-based drugs.

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Bis-pyrazolylpyridine Complexes of Some Transition Metal Ions: Structure-Activity Relationships and Biological Activity

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