Biocompatible Supramolecular Systems Based on Chlorin e6: Preparation, Photophysical Properties

Inna V. Klimenko,^a@ and Anton V. Lobanov^a,b

^aN.M. Emanuel Institute of Biochemical Physics, RAS, 119334 Moscow, Russia

^bN.N. Semenov Federal Research Center for Chemical Physics, RAS, 119991 Moscow, Russia

^@Corresponding author E-mail: inna@deom.chph.ras.ru

DOI: 10.6060/mhc200390k

Macroheterocycles 2020 13(2) 142-146

The synthesis methods as well as the data of spectral-fluorescent properties of novel supramolecular systems based on chlorin e₆(Ce₆) are presented. The effect of various biocompatible excipients such as hydrolyzed polyvinyl alcohol (PVA), poly-N-vinylpyrrolidone (PVP), sodium salt of carboxymethyl cellulose (Na-KMC), dimethylsulfoxide (DMSO), Cremophor® PEG-40 (PEG) on the optical absorption and fluorescence of chlorin e₆ is demonstrated. A red shift of the chlorin e₆ absorption spectrum when using all presented here excipients is a good prerequisite for increasing tissue permeability for visible light. The fluorescence quantum yield _k of chlorin e₆ in systems with all excipients has been calculated. It has been proven, that in all obtained biocompatible systems, except DMSO – Ce₆ system, Ce₆ molecules disaggregate and charge transfer complexes “excipient – Ce₆” are formed. The high efficiency of such systems as PEG  – Ce₆, PVP – Ce₆ and Na-KMC – Ce₆ for fluorescent diagnosis and photodynamic therapy is noted. The conclusions made in the work can be useful during the new photosensitizer controlled aggregation method development.

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Biocompatible Supramolecular Systems Based on Chlorin e6: Preparation, Photophysical Properties

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