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ISSN 1998-9539

Biocompatible Supramolecular Systems Based on Chlorin e6: Preparation, Photophysical Properties

Inna V. Klimenko,a@ and Anton V. Lobanova,b
aN.M. Emanuel Institute of Biochemical Physics, RAS, 119334 Moscow, Russia
bN.N. Semenov Federal Research Center for Chemical Physics, RAS, 119991 Moscow, Russia
@Corresponding author E-mail:
DOI: 10.6060/mhc200390k
Macroheterocycles 2020 13(2) 142-146
The synthesis methods as well as the data of spectral-fluorescent properties of novel supramolecular systems based on chlorin e6 (Ce6) are presented. The effect of various biocompatible excipients such as hydrolyzed polyvinyl alcohol (PVA), poly-N-vinylpyrrolidone (PVP), sodium salt of carboxymethyl cellulose (Na-KMC), dimethylsulfoxide (DMSO), Cremophor® PEG-40 (PEG) on the optical absorption and fluorescence of chlorin e6 is demonstrated. A red shift of the chlorin e6 absorption spectrum when using all presented here excipients is a good prerequisite for increasing tissue permeability for visible light. The fluorescence quantum yield k of chlorin e6 in systems with all excipients has been calculated. It has been proven, that in all obtained biocompatible systems, except DMSO – Ce6 system, Ce6 molecules disaggregate and charge transfer complexes “excipient – Ce6” are formed. The high efficiency of such systems as PEG  – Ce6 , PVP – Ce6 and Na-KMC – Ce6 for fluorescent diagnosis and photodynamic therapy is noted. The conclusions made in the work can be useful during the new photosensitizer controlled aggregation method development.


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