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ISSN 1998-9539

Synthesis of Macrolides with Malonic Fragment and Products of С-Alkylation Reaction from Castor Oil

Galina R. Mingaleeva,@ Marina P. Yakovleva, Kseniya S. Denisova, and Gumer Yu. Ishmuratov
Ufa Institute of Chemistry – Subdivision of the Ufa Federal Research Center of the Russian Academy of Sciences, 450054 Ufa, Russia
@Corresponding author E-mail: mingaleevagalina@yandex.ru
 
DOI: 10.6060/mhc190661m
Macroheterocycles 2020 13(1) 79-82
 
The [1+1]-condensation reaction of natural castor oil (triglyceride of (R,Z)-(+)-12-hydroxy-9-octadecenoic acid) with malonic acid chloride was carried out by one-stage synthesis. Optically active macroheterocycles with four ester groups were obtained, their malonic fragment being additionally alkylated by 1-bromotridecane or 2-(8-bromooctyl)tetrahydro-2H-pyran.
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