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ISSN 1998-9539

Synthesis of New [γ-(Aryl)pyridino]dibenzo-27,28-Diazacrownophanes Containing Two Pyridine Rings

Le Tuan Anh,a@ Nguyen T. T. Huyen,a Pham T. T. Tam,a,b Nguyen T. Dat,a Truong Hong Hieu,c Tran T. T. Van,a Luong T. M. Hanh,a Anatoly T. Soldatenkov,c and Ayalew T. Wodajod

aFaculty of Chemistry, University of Science, Vietnam National University, 100000 Hanoi, Vietnam

bFaculty of Pharmacy, Thai Nguyen University of Medicine and Pharmacy, 250000 Thai Nguyen City, Vietnam

cPeoples’ Friendship University of Russia, 117198 Moscow, Russian Federation

dCollege of Natural and Computational Sciences, University of Gondar, 196 Gondar, Ethiopia

@Corresponding author E-mail:


DOI: 10.6060/mhc190231a

Macroheterocycles 2019 12(3) 307-311


In continuation of developing new cytotoxic compounds, six azacrownophanes containing both 2,4,6-triarylpyridine and 2,6-bis(phenoxymethyl)pyridine moieties were synthesized successfully by one-step domino-condensation of podand 2,6-bis[(2-acetophenyl)oxymethyl]pyridine, arylaldehydes and ammonium acetate according to the conditions of Hantzsch reactions. The compounds 5a-c were selected for cytotoxicity evaluations against human cell lines (HepG2, Lu1, RD, FL and MCF-7). Compound 5b showing the highest cytotoxicity is interesting for the development of promising anticancer drugs. 

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