Журнал "Макрогетероциклы"

Le Tuan Anh,^a@ Nguyen T. T. Huyen,^a Pham T. T. Tam,^a,b Nguyen T. Dat,^a Truong Hong Hieu,^c Tran T. T. Van,^a Luong T. M. Hanh,^a Anatoly T. Soldatenkov,^c and Ayalew T. Wodajo^d

^aFaculty of Chemistry, University of Science, Vietnam National University, 100000 Hanoi, Vietnam

^bFaculty of Pharmacy, Thai Nguyen University of Medicine and Pharmacy, 250000 Thai Nguyen City, Vietnam

^cPeoples’ Friendship University of Russia, 117198 Moscow, Russian Federation

^dCollege of Natural and Computational Sciences, University of Gondar, 196 Gondar, Ethiopia

^@Corresponding author E-mail: huschemical.lab@gmail.com

DOI: 10.6060/mhc190231a

Macroheterocycles 2019 12(3) 307-311

In continuation of developing new cytotoxic compounds, six azacrownophanes containing both 2,4,6-triarylpyridine and 2,6-bis(phenoxymethyl)pyridine moieties were synthesized successfully by one-step domino-condensation of podand 2,6-bis[(2-acetophenyl)oxymethyl]pyridine, arylaldehydes and ammonium acetate according to the conditions of Hantzsch reactions. The compounds 5a-c were selected for cytotoxicity evaluations against human cell lines (HepG2, Lu1, RD, FL and MCF-7). Compound 5b showing the highest cytotoxicity is interesting for the development of promising anticancer drugs.