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ISSN 1998-9539

Synthesis of New [γ-(Aryl)pyridino]dibenzo-27,28-Diazacrownophanes Containing Two Pyridine Rings

Le Tuan Anh,a@ Nguyen T. T. Huyen,a Trương T. Giang,a Pham T. T. Tam,a,b Nguyen T. Dat,a Truong Hong Hieu,c Tran T. T. Van,a Luong T. M. Hanh,a Anatoly T. Soldatenkov,d and Ayalew T. Wodajoe

aFaculty of Chemistry, VNU University of Science, 100000 Ha Noi, Vietnam

bFaculty of Pharmacy, Thai Nguyen University of Medicine and Pharmacy, 250000 Thai Nguyen City, Vietnam

cSaigon Pharmaceutical Science-Technology Centre, University of Medicine and Pharmacy at Ho Chi Minh City, 70000 Ho Chi Minh City, Vietnam

dPeoples’ Friendship University of Russia, 117198 Moscow, Russian Federation

eCollege of Natural and Computational Sciences, University of Gondar, 196 Gondar, Ethiopia

@Corresponding author E-mail: huschemical.lab@gmail.com

 

In continuation in developing new cytotoxic compounds, six azacrownophanes containing both 2,4,6-triarylpyridine and 2,6-bis(phenoxymethyl)pyridine moieties were synthesised successfully by one-step domino-condensation of podand 2,6-bis[(2-acetophenyl)oxymethyl]pyridine, arylaldehydes and ammonium acetate according to the conditions of Hantzsch reactions. The compounds (5a-c) were selected for cytotoxicity evaluations against human cell lines (HepG2, Lu1, RD, FL and MCF-7). Compound 5b showing the highest cytotoxicity is interesting for the development of promising anticancer drugs.

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