Журнал "Макрогетероциклы"

^aSchool of Pharmaceutical Science and Technology, Dalian University of Technology, 116023 Dalian, P. R. China

^bState Key Laboratory of Fine Chemicals, Dalian University of Technology, 116023 Dalian, P. R. China

^cSchool of Chemical Engineering, Dalian University of Technology, 116023 Dalian, P. R. China

^@Corresponding author E-mail: wangss@dlut.edu.cn

 

DOI: 10.6060/mhc181115w

Macroheterocycles 2018 11(4) 378-382

 

In the development of new photosensitizers for cancer therapy, increasing the capacity of intracellular reactive oxygen species (ROS) production is an important strategy. In this paper, artesunate as a ROS generation group was regioselectively introduced to the chlorin e₆ scaffold to obtain four conjugates of chlorin e₆ and artesunate. By irradiation with 440 nm, 630 nm and 660 nm of light source the four conjugates exhibited significantly improved phototoxicity against HepG2 cells compared with chlorin e₆ and artesunate. Irradiation with 440 nm or 660 nm light source gave higher phototoxicity as well as intracellular ROS level.