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ISSN 1998-9539

N-Acylation and N-Alkylation of Bis(benzo)aza-14-Crown-4 Ethers. Novel Hybrid Compound – Bis(furanyl)triazinethiolazacrown Ether

Truong H. Hieu,a Alexandra I. Komarova,b Alexander N. Levov,b Anatoly T. Soldatenkov,b Elena I. Polyakova,b Tuyen V. Nguyen,a,d Dang T. T. Anh,a,d Dat T. Nguyen,c Tran T. T. Van,c and Le Tuan Anhc@
aInstitute of Chemistry, Vietnam Academy of Science and Technology, 100000 Hanoi, Vietnam
bDepartment of Chemistry, Peoples’ Friendship University of Russia, 117198 Moscow, Russia
cFaculty of Chemistry, VNU University of Science, 100000 Hanoi, Vietnam
dGraduate University of Science and Technology, Vietnam Academy of Science and Technology, 100000 Hanoi, Vietnam
@Corresponding author E-mail:
DOI: 10.6060/mhc181002a
Macroheterocycles 2018 11(4) 438-441
Macroheterocycles containing aza-14-crown-4 ether subunit were synthesized by one-step domino reaction. They are interesting objects for study of physicochemical properties and types of transformation. The N-acylated and N-alkylated aza-14-crown-4 ethers were obtained in good yields. The new hybrid compound – bis(furanyl)triazinethiolazacrown ether – was formed by S-alkylation of N-chloroacyl derivative (3). According to the PASS program, these substances can be inhibitors of the permeability of cell membrane and act also as a CYP2H substrate.

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