N-Acylation and N-Alkylation of Bis(benzo)aza-14-Crown-4 Ethers. Novel Hybrid Compound – Bis(furanyl)triazinethiolazacrown Ether

Truong H. Hieu,^a Alexandra I. Komarova,^b Alexander N. Levov,^b Anatoly T. Soldatenkov,^b Elena I. Polyakova,^b Tuyen V. Nguyen,^a,d Dang T. T. Anh,^a,d Dat T. Nguyen,^c Tran T. T. Van,^c and Le Tuan Anh^c@

^aInstitute of Chemistry, Vietnam Academy of Science and Technology, 100000 Hanoi, Vietnam

^bDepartment of Chemistry, Peoples’ Friendship University of Russia, 117198 Moscow, Russia

^cFaculty of Chemistry, VNU University of Science, 100000 Hanoi, Vietnam

^dGraduate University of Science and Technology, Vietnam Academy of Science and Technology, 100000 Hanoi, Vietnam

^@Corresponding author E-mail: huschemical.lab@gmail.com

DOI: 10.6060/mhc181002a

Macroheterocycles 2018 11(4) 438-441

Macroheterocycles containing aza-14-crown-4 ether subunit were synthesized by one-step domino reaction. They are interesting objects for study of physicochemical properties and types of transformation. The N-acylated and N-alkylated aza-14-crown-4 ethers were obtained in good yields. The new hybrid compound – bis(furanyl)triazinethiolazacrown ether – was formed by S-alkylation of N-chloroacyl derivative (3). According to the PASS program, these substances can be inhibitors of the permeability of cell membrane and act also as a CYP2H substrate.

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N-Acylation and N-Alkylation of Bis(benzo)aza-14-Crown-4 Ethers. Novel Hybrid Compound – Bis(furanyl)triazinethiolazacrown Ether