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ISSN 1998-9539

Calixarene Derivatives for (Nano)Biotechnologies

Roman Rodik, Mykola Poberezhnyk, and Vitaly Kalchenko@
The article is devoted to 75th anniversary of Academician A. Yu. Tsivadze
Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 02660 Kyiv, Ukraine
@Corresponding author E-mail: vik@ioch.kiev.ua
 
DOI: 10.6060/mhc171150k
Macroheterocycles 2017 10(4-5) 421-431 
 
This review summarizes the author's research in the field of bio-medical application of modified calixarenes as well as their nano-associates. The paper includes results of design and investigation of the calixarenes as intracellular transport modulators of Ca and Na cations, as well as effective and selective phosphatases inhibitors. The antibacterial and anticoagulant properties of series water-soluble positively or negatively charged calixarenes are described. Also, utilization of calixarenes for hierarchical formation of nanoparticles for nanobiotechnological application (DNA transfection and bio-imaging) is discussed.

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