Synthesis of Macroheterocycles with Nitrogen-Containing and Ester Fragments from Undecylenic Acid

Marina P. Yakovleva,^@ Galina R. Mingaleeva, Kseniya S. Denisova, Timur R. Nugumanov, Aleksandr G. Tolstikov, and Gumer Yu. Ishmuratov

Ufa Institute of Chemistry of the Russian Academy of Sciences, 450054 Ufa, Russia

^@Corresponding author E-mail: insect@anrb.ru

DOI: 10.6060/mhc170727y

Macroheterocycles 2018 11(2) 193-196

Synthesis of three potentially biologically active 34- and 36-membered macroheterocycles with nitrogen-containing and ester fragments using undecylenic acid is developed. It was based on [1+1] condensation of the intermediate oxybis(ethane-2,1-diyl)bis(10-oxoundecanoate) with full dihydrazides of malonic, glutaric or 2,6-pyridinedicarboxylic acids. The structure of the obtained compounds is confirmed by IR and NMR spectroscopy and mass spectrometry.

References:

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1. Ishmuratov G.Yu., Yakovleva M.P., Tolstikov G.A. Chem. Nat. Compd. 2000, 36, 105–119. (in Russ.) [Ishmuratov G.Yu., Yakovleva M.P., Tolstikov G.A. Khim. Prirod. Soed. 2000, 87–96.].
https://doi.org/10.1007/BF02236410

2. Chemical Encyclopedic Dictionar (Knunyants I.L., Ed.), Moscow: Soviet Encyclopedia, 1983. 792 p. (in Russ.)

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Synthesis of Macroheterocycles with Nitrogen-Containing and Ester Fragments from Undecylenic Acid

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