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ISSN 1998-9539

Cytotoxic Chlorin e6 Derivatives with One or Two 4,5-Dichloro-1,2-thiazole Fragments

D. V. Belykh,a@ M. V. Malshakova,a A. V. Kletskov,b E. S. Ivanova,cY. V. Dutikova,c V. I. Potkin,b and A. A. Shtilc

aInstitute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, 167982 Syktyvkar, Russian Federation

bInstitute of Physical Organic Chemistry of the National Academy of Sciences of Belarus, 220072 Minsk, Republic of Belarus

cBlokhin National Medical Research Center of Oncology, 115478 Moscow, Russian Federation

@Corresponding author E-mail: belykh-dv@chemi.komisc.ru, belykh-dv@mail.ru

 

DOI: 10.6060/mhc170726b
Macroheterocycles 2018 11(3) 269-272

 

We report the synthesis of chlorin е6 derivatives with one or two 4,5-dichloro-1,2-thiazole fragments. The chlorin and dichloroisothiazole cycles were conjugated by acylation of amino groups in peripheral substituents of the chlorin macrocycle with chloroanhydride of 3-carboxy-4,5-dichloro-1,2-thiazole. At micromolar concentrations the new compounds evoked dark cytotoxicity for the human colon carcinoma cell line..

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