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ISSN 1998-9539

Liquid Silyl Derivative of beta-Cyclodextrin

Askar K. Gatiatulin,a@ Marat A. Ziganshin,a Galina I. Kurochkina,b Artem V. Popkov,b Mikhail K. Grachev,b and Valery V. Gorbatchuka
aA.M. Butlerov Institute of Chemistry, Kazan Federal University, 420008 Kazan, Russia
bInstitute of Biology and Chemistry, Moscow State Pedagogical University, 119021 Moscow, Russia
@Corresponding author E-mail:
DOI: 10.6060/mhc170520g
Macroheterocycles 2017 10(2) 233-237

Per-6-О-(tert-butyl)(diphenyl)silyl-β-cyclodextrin was found to form metastable liquid phase, which is unusual for cyclodextrin mono-derivatives under ambient conditions. Also, it can exist in a solid amorphous state as a stable molecular glass. Conditions and parameters of phase transitions between crystal, glassy and liquid forms were determined. The studied compound is soluble in various solvents. Crystallization from its solutions and overcooled melt results in formation of two different polymorphs. The liquid mono-derivative of beta-cyclodextrin is amphiphilic and preferable for application in solutions, in pure form or even as a solvent for substrates with various structures.


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