Influence of New N-Methylquinolinyl Porphyrins on Different Candida albicans Development Forms

Mariya Yu. Rusakova,^a@ Olga V. Ruschak,^b Sergey V. Vodzinskiy,^c and Yuriy V. Ishkov^c

^aBiotechnological Scientific-Education Center, I.I. Mechnikov Odessa National University, 65082 Odessa, Ukraine

Microbiology, Virology and Biotechnology Department, I.I. Mechnikov Odessa National University, 65082 Odessa, Ukraine

^cProblem Scientific-Research Laboratory, I.I. Mechnikov Odessa National University, 65082 Odessa, Ukraine

^@Corresponding author E-mail: rusamariya@yandex.ru

DOI: 10.6060/mhc170396r

Macroheterocycles 2017 10(3) 289-294

The activity of new N-methylquinolinyl porphyrins against different morphological forms of Candida albicans (unattached, free-dividing cells, as well as structures formed in the process of biofilm maturation) was characterized. Modification of porphyrin molecules by N-methyl-6-quinolinyl increases the fungicidal effect on the yeast cells, in contrast to N-methyl-7-quinolinyl derivatives that are effective against hyphal structures. Candida albicans biofilm cells are more resistant to low concentrations of the studied compounds however the significant inhibition of the microbial community is in the presence of 1 µM.

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Influence of New N-Methylquinolinyl Porphyrins on Different Candida albicans Development Forms

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