Investigation of Ion–Molecular Complexes of beta–Cyclodextrin with Proteins and Metals in Gas Phase

Yury I. Kostyukevich,^a,b,c,d@ Alexey S. Kononikhin,^b,d Anna E. Bugrova,^c Natalia L. Starodubtzeva,^b Igor Popov^c,d and Eugene Nikolaev^a,b,c,d

^aSkolkovo Institute of Science and Technology, 143025 Skolkovo, Russian Federation

^bInstitute for Energy Problems of Chemical Physics Russian Academy of Sciences, 119334 Moscow, Russia

^cEmanuel Institute for Biochemical Physics Russian Academy of Sciences, 119334 Moscow, Russia

^dMoscow Institute of Physics and Technology, 141700 Dolgoprudnyi, Moscow Region, Russia

^@Corresponding author E-mail: yura542@gmail.com

DOI: 10.6060/mhc161178k

Macroheterocycles 2017 10(1) 110-116

It is shown that the temperature of the desolvating capillary of the electrospray ionization source has a significant impact on the formation of complexes of cyclic oligosaccharides with proteins and metals. The complexes with proteins undergo decomposition upon temperature rise. Simultaneously complexes with metals consisting of several metal atoms and a few molecules of sugar appear. Besides novel oligosaccharides complexes with cations of metals in high oxidation states (Th⁴⁺) and noncovalent complexes of DNA primers with several molecules of beta-cyclodextrin have been obtained.

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Investigation of Ion–Molecular Complexes of beta–Cyclodextrin with Proteins and Metals in Gas Phase

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