Synthesis of Novel Labdanoid-Based Macroheterocycles Using Click-Cycloaddition Reaction Protocol

Yurii V. Kharitonov,^a,b Makhmut M. Shakirov,^a and Elvira E. Shults^a,^b@

^aNovosibirsk Institute of Organic Chemistry Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia

^bNovosibirsk State University, 630090 Novosibirsk, Russia

^@Corresponding author E-mail: schultz@nioch.nsc.ru

DOI: 10.6060/mhc160959s

Macroheterocycles 2017 10(1) 117-122

A convenient synthetic method to diterpenoid dialkyne 18-propargyloxy-16-[(prop-2-yn-1-yloxi)methyl]labda-8(17),13,15-triene in the common yield of 34 % from the natural plant diterpenoid lambertianic acid was developed. 1,2,3-Triazolyl containing macroheterocyclic compounds with an integrated diterpenoid fragment have been prepared by CuAAC reaction of the labdanoid dialkyne with organic diazides.

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Synthesis of Novel Labdanoid-Based Macroheterocycles Using Click-Cycloaddition Reaction Protocol

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