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ISSN 1998-9539

Synthesis of Novel Labdanoid-Based Macroheterocycles Using Click-Cycloaddition Reaction Protocol

Yurii V. Kharitonov,a,b Makhmut M. Shakirov,a and Elvira E. Shultsa,b@

aNovosibirsk Institute of Organic Chemistry Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia

bNovosibirsk State University, 630090 Novosibirsk, Russia

@Corresponding author E-mail:


DOI: 10.6060/mhc160959s

Macroheterocycles 2017 10(1) 117-122


A convenient synthetic method to diterpenoid dialkyne 18-propargyloxy-16-[(prop-2-yn-1-yloxi)methyl]labda-8(17),13,15-triene in the common yield of 34 % from the natural plant diterpenoid lambertianic acid was developed. 1,2,3-Triazolyl containing macroheterocyclic compounds with an integrated diterpenoid fragment have been prepared by CuAAC reaction of the labdanoid dialkyne with organic diazides.


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