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ISSN 1998-9539

Novel Photosensitizer Based on Bacteriopurpurinimide and Magnetite Nanoparticles

N. V. Suvorov,a@ M. A. Grin,a A. M. Popkov,a A. S. Garanina,b A. F. Mironov,a and A. G. Majougab,c
aMoscow Technological University (MITHT), 119571 Moscow, Russia
bNational University of Science and Technology “MISIS”, Biomedical nanomaterials laboratory, 119991 Moscow, Russia
cM.V. Lomonosov Moscow State University, Chemistry Department, 119991 Moscow, Russia
@Corresponding author E-mail:
DOI: 10.6060/mhc160645s
Macroheterocycles 2016 9(2) 175-179
A method of O-propyloxime-N-propoxybacteriopurpurinimide (dipropoxy-BPI) immobilization on magnetite nanoparticles was developed, which allows to overcome the photosensitizer aggregation, maintain high fluorescence of nanoparticles with loaded PS, and give to the latter the ability to dissolve in water. Biological tests on two lines of prostate cancer cells showed that the dipropoxy-BPI intracellular accumulation efficiency depends on tumor cells type and PS dosage forms..



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