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The First Macrocyclic Glycoterpenoid Having Glucosamine and Isosteviol Moieties

Bulat F. Garifullin,a Irina Yu. Strobykina,a Radmila R. Sharipova,a Marionella A. Kravchenko,b and Vladimir E. Kataeva@

aArbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 420088 Kazan, Russia

bUral Research Institute for Phthisiopulmonology, Ministry of Health Protection of the Russian Federation, 620039 Ekaterinburg, Russia

@Corresponding author E-mail: kataev@iopc.ru

 

DOI: 10.6060/mhc160314k
Macroheterocycles 2016 9(3) 320-322

 

The first macrocyclic glycoterpenoid possessing two glucosamine residues and two moieties of diterpenoid isosteviol has been synthesized. It inhibited the in vitro growth of the H37Rv strain of M. Tuberculosis at the MIC value
of 12.5 μg/mL

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