A Practical Synthesis of 4’-Fluorospiro[cyclopropane-1,3’-indol]-2’(1’H)-one: a Valuable Terminal Building-Block for Biologically Active Podands

Alexandre S. Babushkin, Maxim B. Nawrozkij,^@ Ivan A. Novakov, and Alexandre S. Yablokov

Volgograd State Technical University, 400005 Volgograd, Russian Federation

^@Corresponding author E-mail: maxim.nawrozkij@vstu.ru

DOI: 10.6060/mhc160110n

Macroheterocycles2016 9(1) 50-53

A practical one-pot synthesis of 4’-fluorospiro[cyclopropane-1,3’-indol]-2’(1’H)-one, including the treatment of 1-(2,6-difluorophenyl)cyclopropane-1-carbonitrile with potassium hydroxide in boiling glycol, as a key step, is described. The title product is recognized as a promising terminal building block for the novel biologically active podands..

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A Practical Synthesis of 4’-Fluorospiro[cyclopropane-1,3’-indol]-2’(1’H)-one: a Valuable Terminal Building-Block for Biologically Active Podands

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