Synthesis of Macrolides with Nitrogen Containing Fragments

Gumer Yu. Ishmuratov,^@Marina P. Yakovleva, Galina R. Mingaleeva, and Alexander G. Tolstikov

Institute of Organic Chemistry, Ufa Scientific Centre of RAS, 450054 Ufa, Russia

^@Corresponding author E-mail: insect@anrb.ru

Macroheterocycles 2011 4(4) 270-310

DOI: 10.6060/mhc2011.4.06

Received 15.06.2011
Accepted 29.07.2011

This overview summarizes the materials on the synthesis of macrolides with nitrogen-containing fragments using
macrolactonization, macroamidization and metathesis reactions at the key cyclization stage. The undying interest in
macrolide synthesis is due to the fact that substances with powerful antibiotic (antimicrobial, antiviral, antiparasitic)
and antitumor functions have been found among this class of organic compounds. Furthermore, there is evidence for
positive effects of pharmacophoric nitrogen-containing (hydrazide, amine, amide, pyrrolidone, pyrrolizidine, oxazole,
etc.) fragments in the macrolide molecules on identification or intensification of anti-inflammatory, analgetic, antiviral
and antimicrobial, fungicidal, anticancer and anti-tumor as well as immunomodulating activities.

Keywords: Macrolides with nitrogen containing fragments, synthesis, biological activity, application.

MHC2011_t04n04_270-310.pdf (4.36 MB)

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