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ISSN 1998-9539

Highly Versatile Synthetic Approach to Oligopyridines and Derivatives by Kröhnke-type Ring-closure Reactions

Daniel Caterbow and Ulrich Ziener@


University of Ulm, Institute of Organic Chemistry III, Albert-Einstein-Allee 11, D-89081 Ulm, Germany

@Corresponding author E-mail:


Macroheterocycles 2011 4(4) 249-264


DOI: 10.6060/mhc2011.4.04


Received 16.08.2011
Accepted 20.09.2011


The synthesis of a large variety of different conjugated oligopyridines and derivatives with electron poor and/or rich
peripheral substituents and with pyridine and other (hetero)aromatic cores by the highly versatile Kröhnke-type
synthesis is described. Simple electronic and steric considerations of the participating unsaturated ketones (chalcones)
allow a rough estimation of the synthetic accessibility of the desired compounds.


MHC2011_t04n04_249-264.pdf  (1,54 MB)




MHC2011_t04n04_249-264.pdf1.54 MB