Synthesis, Characterization and Antimicrobial Activity of 4-Oxo-thiazolidines and 5-Arylidene Derivatives of 2-Methylimidazoles

Rajiv Dua,^@ S. K. Srivastava, and S. D. Srivastava

Synthetic Organic Medicinal Chemistry Laboratory, Department of Chemistry, Dr. H.S. Gour University, Sagar (M.P.),
India

^@Corresponding author E-mail: duanobleheights@gmail.com

DOI: 10.6060/mhc2010.1.82

Macroheterocycles 2010 3(1) 82-85

As a part of systematic investigation of synthesis and biological activity of 4-oxothiazolidines and their 5-arylidene derivatives several [N1-(2-aryl-4-oxo-1,3-thiazolidinylamino)acetyl]-2-methylimidazoles 4a-j and [N1-(5-arylidene-2-aryl-4-oxo-1,3-thiazolidinylamino)acetyl]-2-methylimidazoles 5a-j have been synthesized from N1-(hydrazino-acetyl)-2-methylimidazole, 2, using 2-methylimidazole as the starting material. All the synthesized products were evaluated for their antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxisporium and Trichoderma viride and antibacterial activity against Bacillus substilis, Escherichia coli, Klebsiella pneumoneae and Streptococcus aureus respectively. The structures of all the synthesized compounds have been determined by their spectral and microanalytical data.

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