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ISSN 1998-9539

Catalytic Effect of Thioles in Oxidation of the Vinyl Group to Aldehyde in Chlorophyll a Derivatives

Dmitry V. Belykh,@ and Ekaterina V. Ashikhmina
Institute of Chemistry, Komi Scientific Center, Russian Academy of Sciences, 167982 Syktyvkar, Russia
@Corresponding author E-mail: belykh-dv@chemi.komisc.ru, belykh-dv@mail.ru
It is shown that the vinyl group of chlorophyll a derivatives (methylpheophorbide a, methylpyropheophorbide a, 13-amides chlorin e6) can be oxidized to the aldehyde under mild conditions by atmospheric oxygen in the presence of thiols as catalysts. The corresponding aldehyde can be obtained in 50-55% yields. The possible mechanism of the catalytic action of thiols in the oxidation of the vinyl group is proposed.
Keywords: Chlorophyll a, methylpheophorbide a, methylpyropheophorbide a, 13-amides chlorin e6, oxidation, thiols, catalysis.


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